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Tiginor 10mg Tablet 1 Strip
Tiginor (atorvastatin) selectively inhibits the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol production. Blocking this enzyme lowers cholesterol synthesis in the liver and increases LDL receptor activity, enhancing LDL clearance from the bloodstream.
- Absorption: Rapidly absorbed, peaking within 1–2 hours. Bioavailability of the active drug is ~14%, while ethe nzyme inhibition effect is ~30%.
- Distribution: Broadly distributed (volume ~381L); ~98% bound to plasma proteins; limited entry into red blood cells.
- Metabolism: Extensively metabolized by CYP3A4 into active metabolites that significantly contribute to its therapeutic effect.
- Excretion: Mainly eliminated via bile; less than 2% excreted in urine. The drug’s half-life is about 14 hours, but enzyme inhibition lasts 20–30 hours.
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✅ Description:
Tiginor is prescribed alongside dietary measures to lower elevated levels of total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides in cases where diet and non-drug interventions are insufficient. Its uses include:
- Lowering total and LDL cholesterol in patients with heterozygous or homozygous familial hypercholesterolemia.
- Managing high cholesterol and triglycerides in mixed dyslipidemia (Fredrickson types IIa and IIb).
- Treating elevated triglyceride levels in hypertriglyceridemia (Fredrickson type IV).
- Treating dysbetalipoproteinemia (Fredrickson type III).
- Reducing ischemic heart events in patients with coronary artery disease who have raised LDL cholesterol, whether symptomatic or asymptomatic.
- Lowering cholesterol in patients with hypercholesterolemia related to diabetes or post-renal transplantation.
Take only as prescribed by a registered physician.
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✔️ Side Effects
Generally well-tolerated. Common side effects include:
Gastrointestinal: Constipation, gas, indigestion, abdominal pain
Other: Headache, infection, rash, muscle/joint pain, fatigue, back pain
✔️ Dosage & Administration
- Adults with high cholesterol or mixed lipid disorders: Start at 10 mg daily; may increase to 80 mg daily depending on response and LDL reduction needed.
- Children (10–18 years): Start at 10 mg daily; max 20 mg unless treating familial hypercholesterolemia, in which case max is 80 mg.
Coronary event prevention: Begin at 10 mg/day, adjust based on lipid profile.
Can be taken any time of day, with or without food. Lipid levels should be re-evaluated within 2–4 weeks of dose changes.
Continue cholesterol-lowering diet during treatment.
- Elderly: Slightly higher drug levels; typically more effective at lowering LDL.
- Children: Data limited; use under specialist supervision.
- Renal Impairment: No dose adjustment needed.
- Hemodialysis: Unlikely to clear the drug due to high protein binding.
- Liver Impairment: Significantly higher plasma levels; use with caution.
✔️ Drug Interactions
- Increased risk of muscle toxicity: When used with cyclosporine, fibrates, niacin, erythromycin, or azole antifungals.
- Antacids: Reduce atorvastatin plasma levels by ~35% but don’t affect LDL-C reduction.
- Colestipol: Lowers atorvastatin levels but enhances LDL-lowering effect when combined.
- Digoxin: Levels rise ~20%; monitor.
- Oral contraceptives: Increases hormone levels; consider when choosing a contraceptive.
- Warfarin: No significant impact on clotting time.
✔️ Contraindications
- Allergy to atorvastatin or any excipients.
- Active liver disease or persistent unexplained liver enzyme elevation.
- History of adverse effects from statins.
✔️ Pregnancy & Lactation
- Pregnancy: Not recommended—may harm the fetus. Discontinue if pregnancy is confirmed or planned.
- Lactation: Atorvastatin may pass into breast milk and could harm a nursing infant; avoid use while breastfeeding.
✔️ Precautions
- Liver function: Test before starting and monitor periodically.
- Muscle issues: Stop if signs of myopathy or high CPK levels appear.
Use cautiously in patients with liver disease or high alcohol intake.
✔️ Storage
Store in a cool, dry place below 30°C. Protect from heat and light. Keep out of children's reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
